Does micro RNA database need re-examining?

The criteria for miRNA gene definition were settled several years ago for general organisms and for plants. However, Meng, Y. et al. found several evidences that point to the fact that a number of the currently registered miRNA genes need re-examination. Their structure- and expression-based re-examination of available plant miRNA genes in miRBase showed an “unsatisfied scene”.  They proposes a structure- and expression based strategy to validate a set of defined miRNA genes or annotate novel ones based on currently available sRNA HTS (high throughput sequencing) data sets. To read more…

Meng, Y. et al. Are all miRBase registered microRNAs true? A structure and expression-based re-examination in plants. RNA Biol. 2012. 9: 249-253.

Rate of aquisition of miRNA families over geological time. Ref. Taylor et al. Trends in plant science 2014

Rate of aquisition of miRNA families over geological time. Ref. Taylor et al. Trends in plant science 2014

Is the miRBase corrupted by spurious data? Taylor, R. et al.  evaluated the present day published repertoire of plant miRNAs to determine the correctness of their annotation. They explored the prevailing hypotheses on the tempo and mode of miRNA evolution within the plant kingdom. They have proposed a phylogenetic framework, within which they organise the database of valid plant miRNAs, that not only provides  a powerful perspective within which to trace evolution of miRNA families but also to predict the miRNAome of unstudied plant species. To read more…

Taylor, R. et al. Evolutionary history of plant microRNAs. Trends in Plant Science 2014. 19 (3): 175-182.

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